The structural and therapeutic diversity coupled with commercial viability of small heterocyclic molecules has fascinated organic and medicinal chemist. So, a great deal of research was carried out in the field of heterocyclic containing sulphur and nitrogen, because of their immense biological importance. In the present research work, the main motto was to develop new chemical entities of Edaravone. The chemical name of Edaravone is 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one (2, 4-dinitro). The thiadiazole derivatives posses’ different pharmacological and biological activity. The starting material 3-methyl-1-substituted-1H-pyrazol-5(4H)-ones (1) were synthesized in high yields according to reported method using by the treatment of ethyl acetoacetate with appropriate 1-phenylhydrazine. Ethyl 2-(4, 5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl) acetate (2) was synthesized by reaction of ethyl chloroacetate with (1). 1-(2-(4, 5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl) acetyl) thiosemicarbazide (3) prepared by reaction of thiosemicarbazide with (2) in presence of solvent methanol. 4-((5-amino-1, 3, 4-thiadiazol-2-yl) methyl)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one (4) synthesized by reaction of (3) with con. H2SO4 and ammonia kept overnight. 4-((5-(4-substituted benzylideneamino)-1, 3, 4-thiadiazol-2-yl) methyl)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one (MG1-MG4) synthesized by using compound 4 and substituted aromatic aldehydes in presence of methanol as solvent. The structures of newly synthesized compounds were characterized by TLC and FT-IR. The newly synthesized compounds were screened for antibacterial, antifungal activity.
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